A genetic mutation that does not cause a change in the amino acid sequence of the resulting protein can still alter the protein’s expected function, according to a new study conducted at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). The study shows that mutations involving only single chemical bases […]

Postmenopausal women who reduce their consumption of dietary fat and have been treated for early-stage breast cancer may reduce their chances for breast cancer recurrence or a second breast cancer, according to results from the Women’s Intervention Nutrition Study (WINS). WINS was the first large-scale randomized trial to show that a change in diet can […]

The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over time, might retain its full strength indefinitely if used along with a second drug, according to new research in mice conducted by investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, and their partners. The results […]

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), have shown in mice that just a few modifications to a shortened version of a bacterial toxin, called PE38, may be able to improve the efficacy of an immunotoxin that contains PE38 as a new therapy for cancer. As part […]

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), have shown in mice that just a few modifications to a shortened version of a bacterial toxin, called PE38, may be able to improve the efficacy of an immunotoxin that contains PE38 as a new therapy for cancer. As part […]