Positive results of a phase III cancer clinical trial in an uncommon form of leukemia were released today. The results showed that adult patients with previously untreated acute promyelocytic leukemia (APL) who had standard chemotherapy to induce remission of their disease, and then received the chemotherapy drug arsenic trioxide to maintain remission, had a significantly […]

A protein that plays a major role in controlling normal cell growth and promoting tumor development by acting as a chaperone to other proteins was found to require a specific chemical modification for normal function, according to a new study of heat shock protein 90 (Hsp90). This research was conducted at the National Cancer Institute […]

Researchers report that a variation in a portion of DNA strongly predicts prostate cancer risk and that this common variation may be responsible for up to 20 percent of prostate cancer cases in white men in the United States. The research was conducted by investigators from the National Cancer Institute (NCI), part of the National […]

Rapamycin, an FDA-approved drug normally used to help prevent the body from rejecting organ and bone marrow transplants and also used to coat cardiac stents, was highly effective in preventing the development of tobacco-related lung tumors in mice. In a study published in the April 1, 2007 issue of Clinical Cancer Research, researchers at the […]

According to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), the expression of a protein that promotes cell death is reduced in human cancer cells but increased in cells of the normal connective tissue, or stroma, that surrounds a tumor. Elevated expression of this protein, CLIC4, in the […]